Although a high Edinburgh Postnatal Depression Scale does raise the possibility that a woman may benefit from psychiatric support, it does not necessarily mean that she is truly suffering from a psychiatric illness or that she requires medication. Education, reduction of as many stressors as possible and implementation of social supports may be better first steps to consider, however, ultimately medications may still be required. In these cases, both the mother and her partner need to weigh up the risk-benefit ratio and seek professional advice from psychiatric specialists.

General principles that should be followed when utilising psychotropic medications includes lowest possible dose, minimum number of medications possible and tetragenicity. Previous medications that have been effective and liaison with a psychiatrist and or paediatrician regarding possible withdrawal or toxicity issues should also be considered.